Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
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چکیده
منابع مشابه
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier.
The differentiation and reprogramming of cells are accompanied by drastic changes in the epigenetic profiles of cells. Waddington's classical model clearly describes how differentiating cells acquire their cell identity as the developmental potential of an individual cell population declines towards the terminally differentiated state. The recent discovery of induced pluripotent stem cells as w...
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differentiation of stem cells from a pluripotent to a committed state involves global changes in genome expression patterns, the best known as “epigenetic modifications”. epigenetic mechanisms, including histone modifications, dna methylation and non-coding rna-mediated regulatory events are considered as the essential factors to control the heritable cellular memory of gene expression during d...
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1Department of Biosciences, University of Milan, 20133 Milan, Italy 2IRCCS Fondazione Santa Lucia, 00143 Rome, Italy 3National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-8022, USA 4Institute of Translational Pharmacology, National Research Council (CNR), 00133 Rome, Italy 5Stem Cell Metabolism & Regenerative Medicine Group, Ba...
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Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to differentiate into functionally distinct cell types. ES cells proliferate and differentiate without detectable genetic changes, indicating that these processes are controlled by epigenetic factors. Here we describe what is known about the epigenetics of ES cells and speculate that a dynamic balance among at lea...
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Epigenomic regulation is likely to be important in the maintenance of genomic integrity of human pluripotent stem cells, however, the mechanisms are unknown. We explored the epigenomes and transcriptomes of human pluripotent stem cells before and after spontaneous transformation to abnormal karyotypes and in correlation to cancer cells. Our results reveal epigenetic silencing of Catalase, a key...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2013
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2012.0292